A study of environmental factors on miscarriages in women

The objective of this study is to present a profile on the environmental factors and their impact on human infertility. 200 aborted subjects in Chennai metropolitan city, were analyzed for the reasons for miscarriages. A comprehensive, questionnaire related to their medical, surgical family history, life style habits, consanguity, glucose level, blood pressure, type of infertility, BMI etc., were collected, with informed consent of women. The aborted samples were collected and analyzed for chromosomal abnormalities, using chorionic villi sampling culture method. Out of 200 subjects 30% were missed abortion, 27.5 % were due to the absence of cardiac activity in the fetus and in few cases, syndromes and ploidy were observed. With this background a study was initiated to analyze the tentative factors involved in early abortions due to chromosomal abnormalities. It was brought to the light that many of the environmental factors / agents might be multifactorial causation for chromosomal abnormalities in the fetus and consecutively leading to early abortions, where the subjects parent’s genetical background seems to be normal.